Pathogen-tracking questioned

Asbestos findings questioned.

The relationship between autocrine interferon (IFN) production and the expression of class I Major Histocompatibility Complex (MHC) membrane glycoproteins in vitro was investigated in a panel of murine transformed cells of nonhaemopoietic origin. The panel included 11 cell lines of H-2Kb haplotype derived from fibrosarcomas, carcinomas and melanoma, and from transformed fibroblasts. IFN activit...

Key Alzheimer's findings questioned.

When Stephen Strittmatter discovered an unexpected link between key proteins in two devastating brain maladies — Alzheimer’s disease and Creutzfeldt–Jakob disease (CJD) — researchers in the field agreed that he was on to something big. But a year on, conflicting results, including findings published in Nature this month, have clouded that rosy picture and highlight the challenge faced by resear...

Value of e-prescribing questioned.

© 2011 Canadian Medical Association or its licensors CMAJ, October 4, 2011, 183(14) 1575 Decades after Canada’s 33 700 pharmacists began buying computers in the expectation that provincial health systems would connect them with physicians through electronic prescription networks, such information sharing may be inching toward becoming a reality. Although skeptics say the primary rationale for s...

Canada's approach to biosimilars questioned.

Value of monitoring serum immunoglobulins questioned.

Value of Monitoring Serum Immunoglobulins Questioned Our journal club's review of the recent article by Szczeklik al. (EHP 102:302304) found fault on many levels, especially with the concluding recommendation. It would be neither practical nor useful for workers exposed chronically to PAHs to have serum immunoglobulin levels monitored regularly. The use of cross-sectional data regarding serum i...